How to Report and Critique Major Trials in Cardiology from a Statistical Perspective, including Recent Statistical Advances

By Stuart Pocock (London, GBR) & John Gregson (London, GBR)

Thursday Dec 5, 2019 - 9:00 am - 3:00 pm

Part 1: 9:00 AM to 10:30 AM

A critique of some key recent clinical trial in cardiology from a statistician’s perspective (Stuart Pocock)

Part 2: 11:00 AM to 12:30 PM

a) Analysis and interpretation of event outcomes: life beyond the hazard ratio (John Gregson)

b) When to stop (and not stop) a trial early for efficacy, safety or futility (Stuart Pocock)

c) Patients viewpoints: Jillianne Code (Vancouver, CAN); Jeff A. Sloan (Rochester, USA)

Part 3: 1:30 PM to 3:00 PM

a) The value of using repeat events in cardiology trials, and how to allow for the competing risk of death (John Gregson)

b) How to handle the trade-off between efficacy and safety: what’s best for the individual patient (John Gregson)

Learning Objectives

To provide a comprehensive review of major clinical trials in cardiology, as regards their reporting and critical appraisal, including a “cardiologist friendly” update on recent statistical advances.

Target Audience

The content will be aimed at cardiologists, regulators, academic researchers, industry scientists and statisticians: indeed all health professionals wanting to expand their understanding of clinical trial reports and their statistical methods.

Course Description

The course will comprise three 90 minute sessions, covering key aspects of statistical analysis, reporting and critical appraisal of major trials in cardiology, including some recent advances in analysis of event outcomes, and implications for future trial design. All will be presented in a non-technical manner, comprehensible to non-statisticians.

The two lecturers will actively encourage audience participation in a lively discussion, facilitated by an expert cardiologist as lead discussant.

Topics will be illustrated by real examples of cardiovascular trials. The goal is to structure the whole experience to be of direct practical value. Appropriate references to enhance knowledge further will be provided.